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Choriocarcinoma Presenting as Metastatic Carcinoma of Unknown Primary Origin with Growing Masses at Abdominal Wall

以腹壁原位不明腫塊表現之絨毛膜癌

摘要


原位不明癌一直都是臨床醫師面臨的難題。一位50歲女性因一個近一年內逐漸腫大的腹部腫塊來醫院求診。臨床檢查發現除了腹壁病灶,在肺部同時有二顆轉移腫瘤。腹壁腫瘤的切片檢查報告為轉移性麟狀上皮細胞癌。然而,詳細檢查並未發現其他可疑病灶。然而,於腹壁腫瘤切除後,病理診斷發現為絨毛膜癌(choriocarcinoma)。病患血液中的高beta-HCG值也證實了這個診斷。我們回顧探討絨毛膜癌-一個少見但治癒率極高的疾病。當面對女性患者以原位不明癌表現時,絨毛膜癌應做為我們鑑別診斷的可能疾病之一。

並列摘要


Malignancy of unknown primary origin is a challenging clinical problem. We report a 50-year-old woman with growing abdominal wall masses for one year. Tumor biopsy initially reported a metastatic squamous cell carcinoma. Systemic survey did not identify the primary site, but two metastatic lung nodules. The patient was treated with palliative resection of the abdominal wall masses. The surgical pathology, however, proved the diagnosis as choriocarcinoma, which was further confirmed by high serum beta-human chorionic gonadotropin levels. We review this rare but highly curable disease, and highlight the importance of listing choriocarcinoma as a differential diagnosis in women presenting with malignancy of unknown primary origin.

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