Innovative capacity is regarding as a key factor to increase competitiveness. Knowledge infrastructure may be one of the key elements for promoting an area's innovative capacity. The aim of the paper is to explore the effects of the supply of various kinds of knowledge infrastructure on manufacturing innovative outputs (the number of patent) in different areas of Taiwan. The empirical study shows that universities, research and development institutions, and producer services have had significant effects upon the innovative outputs of manufacturing industries, while firms' network did not have.