Fatigue implies a subjectively perceived status lacking energy, in addition to common symptoms manifested in cancer and chronic disease patients, fatigue may also be experienced by healthy people. Cancer-related fatigue has been included in diagnostic items for the International Classification of Diseases (ICD), which is a general problem worldwide. Medical personnel shall acquire background knowledge on fatigue such as definition and characteristics of fatigue, quality of measuring tools, as well as diagnosis and nursing for fatigue, choosing appropriate scales for early assessment, determining the severity and providing nursing intervention to assist the cases in improving fatigue status through health management.