The investigation was based on an A-B-M research design that aimed to investigate the health-related physical fitness impacts of the adapted physical education teaching for two elementary students with moderate intellectual disabilities. All inspection data were analyzed by the descriptive statistics, C statistics, and effect size. The results showed that after two students with moderate intellectual disability received 2 times a week, 50 minutes each time, a total of 8 weeks of adapted physical education teaching, the body composition, cardiorespiratory endurance, muscle strength and muscular endurance, and flexibility of their health-related physical fitness were promoted. Their performances were significantly with the intervention effect better than that before the teaching intervention. After withdrawing intervention, there was still a maintenance effect, but only the body composition had no significant maintenance effect. The adapted physical education teaching in this study can effectively promote the health-related physical fitness of students with moderate intellectual disabilities.