在生醫純鈦金屬上披覆氫氧基磷灰石與銀之研究

生醫植入材中鈦金屬及鈦合金材料之機械性質較原骨骼組織之性質較相近，且與生物體有良好的生物相容性，因此近年來被大量的應用於生物植入體。但金屬植入材料經長時間接觸生物體之細胞與體液、血液時，會有金屬離子的釋出、材料碎片之生成與表面不容易吸附組織細胞等問題存在。所以本研究旨以氫氧基磷灰石(HA,Ca10(PO4)6(OH)2)披覆於純鈦金屬板上做表面改質，其可促進骨組織的沉積與固定。披覆氫氧基磷灰石的方法種類很多，其中使用電化學沉積法沉積氫氧基磷灰石可控制鍍膜厚度與形貌，提供一個高製程控制能力的氫氧基磷灰石披覆層。本研究以純鈦金屬板為試樣，置於60℃的四水硝酸鈣、磷酸二氫氨之混合電解液中，外加直流電源施於試片使之沉積氫氧基磷灰石之披覆層。再使試片浸泡於硝酸銀水溶液中24小時。其不同成分磷酸鈣相的生成依據外加電壓的變化而有所改變。當外加電壓大於3.5伏特時，其鍍膜的主要成份為氫氧基磷灰石(HA)，電壓介於16~19伏特時會有較佳之鈣磷比。以X光繞射(XRD)、掃描式電子顯微鏡(SEM) 、能量分散X光光譜(EDX)、傅里葉轉換紅外光譜(FT-IR)檢測成分，再測量鍵結強度、硬度、表面粗糙度分析鍍層表面機械性質。

關鍵字

生醫植入材；氫氧基磷灰石；電化學沉積；銀；電壓

並列摘要

Pure Titanium and Titanium alloys have been used in biomaterials due to the mechanical properties and bone-compatible. The metal implants contact to blood and tissue in body will release metal ions and scraps. This study use Hydroxyapatite (HA,Ca10(PO4)6(OH)2) coating on pure Ti. Electrochemical deposition can provide a highly free degree of process control and produce a thin film coating of HA. Pure Ti specimens were coated HA by electrochemical deposition at 60℃ from the electrolyte mixtures of Ca(NO3)2•4H2O and NH4H2PO4. Then put into Silver nitrate solution for 24 hours. Different phases of calcium phosphates may be fromed on the base layer depending on the additional voltage. HA was obtained on the surface at the voltage over 3.5 V. Highly pure HA coating was obtained by additional voltage from 16 V to 19 V. Use X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), Fourier transform infrared spectroscopy (FT-IR) examine the component.

並列關鍵字

Biomaterial ； Hydroxyapatite ； Electrochemical deposition ； Ag ； Voltage

參考文獻

[1] J.A. Helsen and H.J. Breme Edited, Metals as Biomaterials, John Wiley & Sons Ltd, (1998).

[2] A. Gefen, “Computational simulations of stress shielding and bone resorption around existing and computer-designed orthopaedic screws” Med. Biol. Eng. Comput., 40, 311–322(2002)。

[3] Jiawei Wang, Klaas de Groot, Clemens van Blitterswijk, Jan de Boer“Electrolytic deposition of lithium into calcium phosphate coatings” dental materials, vol.225, pp.353–359 (2009)

[4] Thomas W. Bauer, and George F. Muschler., “Bone graft materials,” Clinical Orthopaedics and Related Research. Number 371, 2000, pp. 10-27.

[6] Q. Liu, J. R. de Wijn, C. A. van Blitterswijk, “Covalent bonding of PMMA,PBMA, and poly(HEMA) to hydroxyapatite particles,” J. Biomed. Mater. Res.Vol. 40, 1998, pp. 257-263.

國際替代計量

在生醫純鈦金屬上披覆氫氧基磷灰石與銀之研究

全文下載

主題瀏覽