Lower Plasma Neuropeptide Y Level in Patients with Atypical Febrile Convulsions

Translated Titles



林龍昌(Lung-Chang Lin);李威德(Wei-Te Lee);陳怡如(I-Ju Chen);楊瑞成(Rei-Cheng Yang)

Key Words

熱性痙攣 ; 神經胜肽Y ; febrile convulsion ; neuropeptide Y


The Kaohsiung Journal of Medical Sciences

Volume or Term/Year and Month of Publication

26卷1期(2010 / 01 / 01)

Page #

8 - 12

Content Language


Chinese Abstract


English Abstract

Febrile convulsion (FC) is the most common neurological disease in children. Cases with seizures that persist for more than 15 minutes or recurrent seizures within the same febrile illness are considered to be atypical and may have a different prognosis. Neuropeptide Y (NPY), an endogenous anticonvulsant that is widely distributed throughout the central nervous system, including the hippocampus, is known to prevent seizures by increasing the seizure threshold. Based on our previously finding that patients with atypical FC have lower concentrations of NPY, we hypothesized that the concentration of NPY may play a role in the development of atypical FC. To investigate this hypothesis, we used a radioimmunoassay to measure the plasma NPY concentration of 60 children with FC (typical FC, n=46; atypical FC, n=14) and 56 age-matched controls. The atypical FC group had significantly lower concentrations of NPY than children with typical FC and controls (66.47±19.11 pmol/L vs. 88.68±28.50 pmol/L and 86.82±22.66 pmol/L, respectively). Very low NPY levels were found in two patients; one patient (NPY level: 44.75 pmol/L) experienced prolonged seizures lasting for up to 1 hour and the other had recurrent seizures (three seizures) during the same febrile illness (NPY level: 33.53 pmol/L). These results suggest that patients with inadequate NPY inhibitory activity are more susceptible to atypical FC.

Topic Category 醫藥衛生 > 醫藥衛生綜合
Times Cited
  1. 陳倩芳(2011)。系統性護理指導對改變熱性痙攣患童主要照顧者疾病態度、認知、關注及處理行為成效。中山醫學大學護理學系學位論文。2011。1-119。