The present study has been successful prepared the Ca, Li and Cu -doped ITO powders by the processes of co-precipitation and solvothermal, and the doping concentration are 4at%, 6at%, and 8at%. The effects of doped-elements and content on the optical and electricity properties of ITO powders were investigated. By XRD diffraction analysis, we know that the doped-elements would not change the crystal structure of indium tin oxide. Doping Ca in ITO powders lowered its band-gap energy, and then the spectrum appeared the trends of red-shifted by UV-Visible-NIR spectrophotometer. The band-gap energy of Li -doped ITO powders tended to increase and then the spectrums appeared the trends of blue-shifted. With the increment of the doping concentration, the carrier concentration increased and the mobility decreased.