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Respiratory Distress after Transarterial Hepatic Chemoembolization of Hepatocellular Carcinoma: A Case Report

經動脈肝臟化學栓塞後相關之呼吸窘迫

摘要


經動脈肝臟化學栓塞(Transarterial hepatic chemoembolization)是經常用來治療開刀無法治癒的肝惡性腫瘤的方法之一。其併發症約是4.4%,其中大部份是侷限在腹腔內或是和導管置入有關的併發症。相形之下,發生在肺部相關的併發症是非常少見,卻有致命可能。在此報告的個案,是一位新診斷肝癌的病患,並接受經右下橫膈動脈肝臟化學栓塞治療。雖然動脈攝影時,並沒有特殊的血管異常包括動靜分流或畸形,但在接受治療後當天即發生呼吸急促且需要外加氧氣供給,且於數天內惡化至呼吸衰竭而轉至加護病房治療。過程中胸部X光攝影和電腦斷層顯示肺部水腫且有Lipiodol的堆積,顯示為經動脈肝臟化學栓塞的併發症。我們回顧文獻,並探討經動脈肝臟化學栓塞後,發生肺部窘迫的的危險因子及可能的機轉。

並列摘要


Transarterial hepatic chemoembolization (THCE) is commonly used for unresectable hepatic malignancies. Despite its potential benefits, THCE may also result in some complications, among which pulmonary complications could be fatal. We report a critical case of newly diagnosed hepatocellular carcinoma that was treated with THCE as the initial therapy. Although the pre-THCE angiography showed no vascular abnormalities, the patient developed acute pulmonary edema and respiratory distress related to the THCE. We review the literature on THCE and discuss the risk factors and possible pathogenesis of pulmonary complications related to THCE.

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