Adult intussusception caused by colonic adenocarcinoma is rare. We report a 45-year-old woman with a colonic adenocarcinoma that induced ileo-cecal intussusception. The patient presented with symptoms of intermittent right-lower-quadrant abdominal pain, diarrhea, nausea and vomiting that had lasted four days. Abdominal computed tomography demonstrated intussusception from the terminal ileum into ascending colon and ileo-cecal intussusception was confirmed by surgery. The pathological report indicated colonic adenocarcinoma. In conclusion, the clinical signs of adult intussusception may be nonspecific and preoperative diagnosis is difficult. Abdominal computed tomography offers the most useful diagnostic information. Surgical intervention should be considered because of the high risk of the presence of a tumor.