- 期刊
大鼠肝損傷動物模式於中醫傳統方劑柴胡疏肝散變方之抗氧化及細胞色素評估
The Evaluation of Antioxidant and Cytochrome of Traditional Chinese Herb-Modified Chi-Hu-Shu-Gan Powder in Chronic Liver Injury in Rats
摘要
Traditional Chinese herbal medicine has been a spotlight of research interests in recent years. In this study, we evaluate the antioxidative and detoxificative activity of modified Chi-Hu-Shu-Gan (M-CHSG) powder in Sprague-Dawley rats with chronic liver injury which were induced by 5D % carbon tetrachloride (2 mL/kg). The results showed that the treatment with high dose MCHSG significantly decreased the serum levels of AST and ALT, and markedly increased the activity of CAT, GST and CYP 2Et in liver which were compared with the CCl4 group (P ＜ 0.05). We suggested that the M-CHSG had the detoxificative and hepatoprotective effects by modulating the detoxification system (CYP450, GST) and enhancing the activities of some antioxidant enzymes (CAT) which alleviated the liver damage caused by CCI4 also shown by lower liver function index (AST, ALT).
並列摘要
Traditional Chinese herbal medicine has been a spotlight of research interests in recent years. In this study, we evaluate the antioxidative and detoxificative activity of modified Chi-Hu-Shu-Gan (M-CHSG) powder in Sprague-Dawley rats with chronic liver injury which were induced by 5D % carbon tetrachloride (2 mL/kg). The results showed that the treatment with high dose MCHSG significantly decreased the serum levels of AST and ALT, and markedly increased the activity of CAT, GST and CYP 2Et in liver which were compared with the CCl4 group (P ＜ 0.05). We suggested that the M-CHSG had the detoxificative and hepatoprotective effects by modulating the detoxification system (CYP450, GST) and enhancing the activities of some antioxidant enzymes (CAT) which alleviated the liver damage caused by CCI4 also shown by lower liver function index (AST, ALT).
延伸閱讀
- 徐瑞霞、陳勁初（2017）。抗氧化複合組成物配方與CCl_4誘導大鼠肝炎模式中的護肝功能評估。檢驗及品保雜誌，6(4)，186-197。https://doi.org/10.6573/JTQA.201711_6(4).04
- 陳宏銘（2006）。高壓氧氣治療內毒素誘發小鼠全身性發炎反應症候群模式的療效及細胞素影響與對肝臟保護效果之研究〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2006.02370
- Lin, T. C. (2010). 從DMN誘導肝臟纖維化的大鼠動物模型中尋找生物標記並探討肝臟纖維化的可逆機制 [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2010.02998
- Wu, J. P., Ho, T. J., Tsai, C. C., Yeh, Y. L., Lin, C. C., Lin, K. H., Hsieh, D. J. Y., Chen, L. M., Pan, L. F., & Huang, C. Y. (2015). Hepatoprotective Effects of Traditional Chinese Medicine on Liver Fibrosis from Ethanol Administration following Partial Hepatectomy. The Chinese Journal of Physiology, 58(6), 393-403. https://doi.org/10.4077/CJP.2015.BAD339
- Wu, J. P., Ho, T. J., Tsai, C. C., Yeh, Y. L., Lin, C. C., Lin, K. H., Hsieh, D. J. Y., Chen, L. M., Pan, L. F., & Huang, C. Y. (2013). Hepatoprotective Effects of Traditional Chinese Medicine on Liver Fibrosis from Ethanol Administration following Partial Hepatectomy. The Chinese Journal of Physiology, (), 1-11. https://doi.org/10.4077/CJP.2015.BAD339