微奈米生物感測系統在生物醫學的應用

Micro/Nano Biosensing System and Its Application on Biomedicine

張景裕(Ching-Yu Chang) ； 張憲彰(Hsien-Chang Chang)

《科儀新知》 153期 (2006/08) Pp. 17-26

https://doi.org/10.29662/IT.200608.0002

摘要

微奈米生物感測器(micro/nano biosensor)之發展非但為生物醫學研究建構了一個嶄新的平台，也開啟了理、工、醫、農等跨領域研究之必然性的新視野，其結果一方面提供世人可一窺細胞內部或細胞間反應的奧妙，並得以重新驗證先前的假說與理論，另一方面，也在一般生醫檢驗上逐漸展露蹤跡且扮演重要角色。隨著奈米科技一波波的刺激，如今生物感測器也起了不少變化，其應用遂也包羅萬象。本文在簡述其基本感測特性之同時，也匯集了一些新穎且獨特之生物醫學應用詳加說明，除針對以人類血液中各項生化(biochemistry)、免疫(immunological protein)與遺傳分子(genomic nucleotides)為檢測目標，所呈現出的各類微奈米生物感測器舉例之外，並就各項檢測時所能達到的效果與可能遭遇的困難進行剖析，且將現有方法與發展中的技術作比較，嘗試歸納出各類血液檢驗之未來可能的發展與可再著力之處，最後以市場與實用的觀點，提出其未來的挑戰與需求趨勢。

並列摘要

Development of micro/nano biosensors had not only established a fresh platform but also expanded the essential scopes for the biomedical researches which covers science, engineering, medicine and agriculture fields. By these advanced sensing technologies, people can observe the molecules transportation in the cell and the micro interaction between cells, then the prior hypothesizes and theories can be validated with the success of these technologies; on the other hand, these technologies gradually play an important role for the biomedical detection. The biosensor showed a diverse developments and applications with respect to the impact of nano technology. In this article, we briefly described the sensing principle and also some advance and unique characteristics of micro/nano biosensor. The advanced biosensing systems which were developed for the detection of biochemistry, immunological proteins and genomic nucleotides in human blood were taken as examples to compare the developing technologies with current methods; we addressed some possible challenges for the new ones. Finally, we summarized the chances that micro/nano biosensors can play in the molecular diagnosis of human blood, and proposed the future trends and challenges for the new sensing technologies based on the market and practical considerations.