CRF (Cancer-relates fatigue) is defined as distressing, persistent or cognitive tiredness or exhaustion related to cancer or cancer treatment that is not proportional to activity, interferes with usual functioning, and is not relieved by rest. This report is about a case of breast cancer of stage 2. After finishing first and second chemical therapy, the patient became seriously exhausted, aversion to cold, nocturia, etc. This case would belong to 'Kidney-yang deficiency' with Chinese medicine theory. We prescribed some Chinese medicine with the function of 'warmly invigorating Kidney-yang' and 'Strengthen the spleen and stomach'. The fatigue was significantly improved, and the patient became more brave and confident while facing follow-up chemical therapy program.