Abstract: This study examine the manufacture companies, which listed in our nation’s stock & over-the-counter exchanges, for unsymmetrical of information caused by the R&D activities. Further more, because of this unsymmetrical information flow would it cause the inside trade between internal personnel and foreign investors; which will reveal the positive profit after buying and negative after selling. However, the study found, the R&D activities of certain companies would have significant cause of change stock holdings of foreign investments, but not related to internal personnel. Moreover, the study also found that with company that includes R&D activity, the internal personnel would have higher profit of buying stocks, which is as expected; however, not as expected, to sell them would also bring higher profit