開發大氣低溫電漿自主滅菌表面系統

Development of Cold Atmospheric-Pressure plasma system for surface self-sterilization

李彥勳(Yan-Syun Li)

指導教授 ： 王明誠

中原大學/工學院/生物醫學工程研究所/碩士(2015年)

https://doi.org/10.6840/CYCU.2015.00148

摘要

近年大氣電漿在生物醫學應用領域已經有了相當廣泛的研究，能夠在短時間內進行低溫滅菌，其與傳統消毒法相比對人體較為無害。電漿中包含了許多物種如離子、射線、電子以及化學活性物質。這些物種能在短時間內達到滅菌效果。但傳統的電漿反應器形式處理範圍大都侷限在小範圍，為了能夠直接在操作表面產生電漿使其自我進行滅菌，本研究設計了三種新式的電漿反應器，利用介電質阻擋放電原理製作大氣低溫電漿自主滅菌表面系統，此種設計對於其反應器表面有著相當好的滅菌效果，當使用大腸桿菌以及金黃色葡萄球菌進行滅菌實驗時發現分別在4秒及15秒時即可達到D-value，而在12秒及20秒時分別達到完全滅菌。未來若將這種構造的反應器製作於容易細菌汙染的大面積表面如桌面、衛浴設備等，可大大降低細菌造成傳染疾病的威脅性。

關鍵字

大腸桿菌 ； 電漿 ； 金黃色葡萄球菌 ； 殺菌 ； 自主表面滅菌

並列摘要

Biomedical applications of atmospheric pressure plasmas have been extensively investigated. Its ability is to sterilize at relatively low temperatures within a short time. Unlike traditionally chemical disinfection, it's a non-toxic method to the environments or to the users. Plasma generates many reactive species such as ions, rays, electrons and chemical substances. These reactive species can inactivate bacteria in a short time. In the past, the treating area of the plasma was always limited. To be able to generate plasma on the surface directly and to achieve sterilization, in this research, our group therefore developed a new type of plasma reactor. The structure of the surface sterilization system based on the dielectric barrier discharge principle provides a valuable effect for its own surface. It reveals a distinct difference between the original amounts of bacteria with a five-second plasma treatment and shows complete sterilization with a ten-second treatment. The prospective applications of such devices can significantly decrease the threats that caused by bacteria on some easily contaminated objects, for example, maintaining the durability of bathing equipment and the table surface.

並列關鍵字

Plasma ； E. coli ； S.A. ； sterilization ； surface self-sterilization

參考文獻

3. 疾病管制局, 感., 醫院消毒劑的介紹 民國101年3月.

4. Ionita, E.R., et al., Small size plasma tools for material processing at atmospheric pressure. Applied Surface Science, 2009. 255(10): p. 5448-5452.

5. Morfill, G.E., et al., Nosocomial infections-a new approach towards preventive medicine using plasmas. New Journal of Physics, 2009. 11.

6. Wang, J., et al., Tooth Enamel Evaluation After Tooth Bleaching With Hydrogen Peroxide Assisted by a DC Nonthermal Atmospheric-Pressure Plasma Jet. Ieee Transactions on Plasma Science, 2012. 40(9): p. 2157-2162.

7. Klampfl, T.G., et al., Cold Atmospheric Air Plasma Sterilization against Spores and Other Microorganisms of Clinical Interest. Applied and Environmental Microbiology, 2012. 78(15): p. 5077-5082.