The purpose of this study was to investigate the relationship among hope, coping strategy, and psychological well-being of college students. The participants were 18-25 year-old students. There were 293 valid cases. The instruments used in this study included the basic information questionnaire, The Hope Scale, Brief COPE, and Flourishing Scale. The results of this study showed that:(1) hope had a significant influence on coping strategy and psychological well-being. (2) coping strategy had a significant influence on psychological well-being. (3) agency of hope had a significant influence on avoidance coping, pathways of hope had a significant influence on approach coping. (4) hope was found to be an important role between coping strategy and psychological well-being in the path model.