Immunologic Studies in a Silicone Exposed Population a Preliminary Report

矽膠在人體內所產生的免疫反應

黃耀主(Peter Huang) ； 羅賢益(Shian-I Luor) ； 李鐵國(Tit-Kwok Lee) ； 丁效曾(Shiau-Tzen Din) ； 吳瑞星(Simon Wu) ； 張士人(Shih-Zen Chang) ； 呂旭彥(Shiuh-Yen Lu)

《中華民國重建整形外科醫學會雜誌》 4卷1期 (1995/03) Pp. 35-40

https://doi.org/10.7096/JPRSA.199503.0035

摘要

在過去的一年裡，我們針對20位不管是接受矽膠小針注射或是矽膠隆乳手術的女性患者，作臨床症狀及免疫反應的探討。
對這項探討我們歸納出以下幾個可變因素：詳細的健康檢查、免疫球蛋白(IgG、IgM、IgA)、補體(C3、C4)、類風濕因子、抗細胞核抗體、抗DNA抗體、淋巴球分類、臨床症狀及開刀發現。
結果顯示，所有病人都有某種程度的異常，但大部份病人又都沒有症狀發生；14位患者當中有11位表現高濃度抗細胞核抗體。
矽膠與免疫系統間的相互影響仍然不甚明確，但是我們作了一個重要的觀察：抗細胞核抗體與暴露於矽膠的人體有密切的關連；不管此關連是一個起因或影響及是否抗細胞核抗體可能成為早期自體免疫症狀發生前的血清指標，更進一步的探討是很需要的。

並列摘要

The clinical features and immunological studies of 20 women who have exposed to silicone by either direct injection or implantation were evaluated in the past year. We included the followings as the variables in this study: complete physical examination, immunoglobulins (IgG, IgM, IgA), complements (C3, C4), rheumatoid factor, antinuclear antigen (ANA), anti DNA antigen, lymphocyte subpopulations, clinical features, and surgical exploration.
The results reveal all patients who have exposed to silicone show some degree of immunologic abnormalities, but most of them were asymptomatic. High ANA titers were present in 11 of these 14 patients.
It remain unclear how silicone interacts with the immune system. But we did made one important observation: ANAs are closely associated with the silicone exposed populations. Further studies are needed to see whether this relation is one of cause and effect and whether ANAs might be early serological markers preceding development of autoimmune symptoms.

並列關鍵字

Silicone ； Immunoglobulins ； Complement ； Rheumatoid factor ； Antinuclear antigen ； Anti DNA antigen ； Lymphocyte subpopulations ； Autoimmune