The central odontogenic fibroma (CODF), which has been categorized under the subheading of odontogenic tumors of ectomesenchyme, is such an uncommon neoplasm that much of its nature is left uncharted. In this report, we described a 20-year-old female with a painless unilocular radiolucent lesion over left side of mandibular body. Histopathological study showed collagen-rich background with spindle fibroblasts and diagnosis of the central odontogenic fibroma was confirmed. A brief review of the clinicopathological features, management and prognosis of the CODF were going to be presented in this report as well.