- 期刊
The Role of IL-23/1L-17 Axis in Periodontal Diseases: A Literature Review
並列摘要
The interleukin (IL)-23JIL-17 axis is recognized as a novel immune pathway in addition to the traditional T helper 1 (Th1) and Th2 responses. This new Th subtype, which mainly secretes the IL-17 cytokine, is named T helper 17 (Th17). Plenty of research has investigated the correlation between this new pathway and autoimmune diseases, especially rheumatoid arthritis. Those studies assumed that Th17 plays an important role in bone resorption. However, patients with periodontal disease also encounter a bone resorption crisis. Much research has attempted to determine whether periodontitis is a major Th1 or Th2 response, and the answer to this is still controversial. The latest experiments showed that levels of IL-23 and IL-17 are higher in tissues with periodontitis. The results imply that the newly found IL-23/ IL-17 axis may play an important role in periodontitis, and this novel Th subtype could be a new target for understanding the pathogenesis of periodontal diseases. In this article, we review the immune pathway of IL-23/IL-17 and its role in bone resorption, and highlight the role of Th17 in periodontal disease based on some reports.
被引用紀錄
延伸閱讀
- 程季芳、賴玉玲（2005）。Case Report and Literature Review of the Periodontal Full Treatment。中華民國牙周病醫學會雜誌，10(2)，95-110。https://www.airitilibrary.com/Article/Detail?DocID=10279962-200506-10-2-95-110-a
- Nagpal, R., Yamashiro, Y., & Izumi, Y. (2015). The Two-Way Association of Periodontal Infection with Systemic Disorders: An Overview. Mediators of Inflammation, 2015(), 169-177-414. https://doi.org/10.1155/2015/793898
- 胡桂華、周瀅芬、江正陽、邱賢忠（2013）。Aggressive Periodontitis: Full Treatment Case Report and Literature Review。臺灣牙周病醫學會雜誌，18(2)，151-167。https://doi.org/10.6121/TAP.2013.18.2.08
- Solari, J. F., Barrionuevo, P., & Mastronardi, C. A. (2015). Periodontal Disease and Its Systemic Associated Diseases. Mediators of Inflammation, 2015(), 401-402-035. https://doi.org/10.1155/2015/153074
- 黃國精、周大雄、袁國、曾春祺（2002）。The Relationship of IL-1 Gene Polymorphism and Periodontal Disease: Literatures Review。中華民國牙周病醫學會雜誌，7(3)，169-176。https://www.airitilibrary.com/Article/Detail?DocID=10279962-200209-7-3-169-176-a