Cardiogenic pulmonary edema due to gas exchange disorders can cause dyspnea and desatruation. If the patient without treatment, the patient may experience acute respiratory failure and it is a serious and dangerous event. When the heart is impaired, it will increase the afterload and decrease the cardiac output. It will also increase the hydrostatic pressure of pulmonary vein and microvascular circulation. Due to the extravascular volume more than reabsorption in pulmonary microvascular circulation, the fluid shift to the interstitial tissue and alveolar space; this will lead to cardiogenic pulmonary edema. Regarding to patients with mitral regurgitation and cardiogenic pulmonary edema, we will further discuss and research for the benefits for pulmonary edema of using Positive pressure ventilation and high level PEEP.