Complete cardiac catheterization care for patient safety and prevention of complications are highly correlated. The project was using flip learning model to enhance nursing staff to perform complete cardiac catheterization care. Nursing staff perform cardiac catheterization care average integrity rate was 78.33%. According to data analysis found the incorrect reasons include: 1. No clinical care criterion & checklist 2. There are not integrated nursing assessment leaflet and medical advice 3. There are not complete nursing education and training program 4. No health education tools. By developing cardiac catheterization care standards & checklist, using information system to integrate nursing check sheet and doctor's advice, using nip learning model on in-service education courses, production of nursing staff self-study film, using multi-media support health education. Complete cardiac catheterization care rate increased to 98.83 %. The implementation of the project can enhance the nurse professional clinical care quality.