牙周相關疾病與冠狀動脈疾病風險的相關性之研究

A Study Exploring the Correlation between Periodontal Disease and Risk of Coronary Artery Disease

王培子(Pei-Tzu Wang)

指導教授 ： 黃純德

高雄醫學大學/口腔醫學院/口腔衛生科學研究所碩士在職專班/碩士(2011年)

https://doi.org/10.6832/KMU.2011.00122

摘要

支持牙齒周圍的組織稱牙周組織，慢性牙周組織發炎，是細菌感染牙周組織所引起的慢性感染性疾病，當細菌不斷進入血液中，可能引發人體免疫反應，以致體內長期處於發炎狀態，進而增加動脈硬化的風險，引發相關心血管疾病，動脈粥狀硬化與人體發炎反應有關。牙周組織發炎是由細菌感染所引發，是造成口腔感染主要原因之一，近年來也已被證實會藉由牙周致病原的直接或間接因子對冠狀動脈心臟疾病的發生有所影響。年齡、低密度脂蛋白、牙齦炎、齲齒與鈣化指數有正相關，表示有可能為增加粥狀動脈硬化的危險因子。白血球、高密度脂蛋白與鈣化指數有負相關，表示有助於減少冠狀動脈心臟疾病的發生。

關鍵字

鈣化指數 ； 冠狀動脈血管鈣化 ； 牙齦炎評分 ； 牙結石評分

並列摘要

Atherosclerotic complications, including coronary heart disease and stroke are the main causes of human death. To date, it is assumed that atherosclerosis is an inflammatory vascular condition, and certain infectious diseases may provoke atherosclerosis and possibly be one of its risk factors. Chronic periodontitis, perceived as an infectious disease induced by bacteria, is regarded as one of the major causes of oral infection and has also been proved to contribute to the pathophysiology of atherosclerosis via direct or indirect invasion of periodontal pathogens in recent years. The correlation of these two diseases will be discussed and we elucidate their possible links.The number of males in this study is 123. The age is 28 y/o to 83 y/o. The number of females is 61. The age is 30 y/o to 80 y/o. The number of those aged below 50 y/o is 39(21.19%). The number of those aged above 50 y/o is 145(78.8%).
The study showed significant differences in age. Glucose, HbA1c, total cholesterol, HDL, LDL, missing teeth, calcification index in those above 50 years old was greater than below 50 years old.
This study revealed significant differences in gender. The HDL in females was greater than in males. The triglycerin in males was greater than in females. The calcification index in males had the greater predominance. The severity of gingivitis is statistically significantly correlated to the higher calcification index.

並列關鍵字

CaIcification index ； Thickness of calculus ； Gingival index

參考文獻

參考文獻

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