Myofibroma is an uncommon neoplasm characterized by myofibroblastic proliferation. The tumor may present as single or multiple nodules of soft tissue, bone, or internal organs. When encountered in the jaws, the lesions exhibit clinical and radiographic features suggestive of several odontogenic and non-odontogenic neoplasms. Myofibromas of the jaws are usually well-demarcated, but sometimes can be poorly delineated or infiltrated that may result in misdiagnosis and mistreatment. In this article, a case of myofibroma of the mandible of a 10-year-old Taiwanese girl is reported. The patient received local wide excision of the lesion and remained disease free with regular follow-up for 6 years. Details of the clinical features, histopathologic diagnosis, and management of the case are provided to augment the paucity of literature available to clinicians managing the rare disease.