W/O/W型海藻酸鈣膠囊之製備及其制放性的探討

Preparation and Controlled Release Properties of W/O/W Calcium Alginate Capsules

巢育誠(Y. C. Chao) ； 陳忠益(C. Y. Chen) ； 黃國雄(K. H. Huang) ； 張志鵬(C. P. Chang)

《華岡紡織期刊》 14卷2期 (2007/06) Pp. 111-117

https://doi.org/10.29984/JHGT.200706.0002

摘要

本研究利用簡單凝膠包覆法製備W/O/W型海藻酸鈣膠囊。以水溶性染料冰微粒作為芯材，海藻酸鈉作為膠囊的殼材，藉由改變交鏈劑濃度對膠囊的成形性進行探討。本實驗並將實驗數據以指數函數進行回歸分析，對染液自膠囊內經由殼膜往外擴散的行為進行解析。結果顯示隨著交鏈劑濃度的增加，染液（膠囊包覆物）自內而外的釋出速率呈現減緩的情形。經由本實驗得到在條件為1.0%氯化鈣和1.0%海藻酸納時可獲得最佳的制放效果。

關鍵字

簡單凝膠包覆法 ； W/O/W型 ； 海藻酸鈣 ； 微膠囊 ； 緩釋效果

並列摘要

In this study, W/O/W type calcium alginate capsules were prepared by a simple coacervation method. The alginate acid was used as wall membrane and pure water mixed with yellow water-soluble dye was used as core material. In order to investigate the formation of microcapsules, the concentration of alginate acid and cross-linking agent was discussed at various conditions. The effect of controlled release of core material was evaluated by an exponential function which usually analysis to relaxation behavior. The results indicated that the release rate of dye was decreased with increasing the concentration of alginate acid and cross-linking agent. The optimal condition was at the concentration of 1.0% alginate and 1.0% CaCl2.

並列關鍵字

simple coacervation ； W/O/W type ； calcium alginate ； microcapsules ； controlled release