Due to rapid technological changes, product collaborative design has become a significant requirement for enterprises to enhance their competitiveness. Since partners are always involved in product design, how to develop an effective collaborative mechanism and select suitable partners is a major consideration in the collaborative design. This study develops a one-to-many and multi-stage negotiation framework for collaborative product design among customer, enterprise, and suppliers. Based on three collaborative models, the study simulates the negotiation process among the three participants with different strong-or-weak position combinations for achieving design specifications, analyzing the cooperation effect of suppliers with customer and enterprise, and selecting suitable supplier. We believe that this study can serve as a reference of the development one-to-many and multi-stage negotiation mechanism for collaborative product design.