This study examined the relationship among work-family conflicts, job burnout, and social support using 165 female professionals from the companies in Science-Based Industrial Park, Hsinchu, in particular, whether social support played a moderating role between work-family conflict and job burnout. The results indicated that: (1) Work-family conflict had significant positive effect on job burnout. (2) Social support was negatively associated with work-family conflict and job burnout separately. (3) Social supports have some moderating effect between work-family conflicts and job burnout. The high supports from others may sharpen the positive effects of the work-family conflicts on emotional exhaustion and cynicism.